Autoreactive CD8 T cells in organ-specific autoimmunity: Emerging targets for therapeutic intervention

被引：160

作者：

Liblau, RS

Wong, FS ^{[1
]}

Mars, LT

Santamaria, P

机构：

[1] Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England

[2] Toulouse Univ Hosp, INSERM U563, Toulouse, France

[3] Toulouse Univ Hosp, Immunol Lab, Toulouse, France

[4] Univ Calgary, Fac Med, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada

来源：

IMMUNITY | 2002年 / 17卷 / 01期

关键词：

D O I：

10.1016/S1074-7613(02)00338-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized. Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders. As such, these T cells now become an attractive target for therapeutic intervention.

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页码：1 / 6

页数：6

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