Gold opens mitochondrial pathways to apoptosis

被引:23
作者
McKeage, MJ [1 ]
机构
[1] Univ Auckland, Div Pharmacol & Clin Pharmacol, Auckland 1, New Zealand
关键词
apoptosis; auranofin; bcl-2; cancer chemotherapy; cytochrome c; gold complexes; mitochondria; mitochondrial permeability transition; thioredoxin reductase;
D O I
10.1038/sj.bjp.0704822
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1081 / 1082
页数:2
相关论文
共 10 条
  • [1] Mitochondrion as a novel target of anticancer chemotherapy
    Costantini, P
    Jacotot, E
    Decaudin, D
    Kroemer, G
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (13) : 1042 - 1053
  • [2] Mitochondria as the central control point of apoptosis
    Desagher, S
    Martinou, JC
    [J]. TRENDS IN CELL BIOLOGY, 2000, 10 (09) : 369 - 377
  • [3] Mitochondria: execution central
    Gottlieb, RA
    [J]. FEBS LETTERS, 2000, 482 (1-2): : 6 - 12
  • [4] Human placenta thioredoxin reductase - Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds
    Gromer, S
    Arscott, LD
    Williams, CH
    Schirmer, RH
    Becker, K
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) : 20096 - 20101
  • [5] MCKEAGE MJ, 2002, IN PRESS COORD CHEM
  • [6] MIRABELLI CK, 1985, CANCER RES, V45, P32
  • [7] Mitochondria as target for antiischemic drugs
    Morin, D
    Hauet, T
    Spedding, M
    Tillement, JP
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2001, 49 (1-2) : 151 - 174
  • [8] Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability
    Rigobello, MP
    Callegaro, MT
    Barzon, E
    Benetti, M
    Bindoli, A
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1998, 24 (02) : 370 - 376
  • [9] Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative
    Rigobello, MP
    Scutari, G
    Boscolo, R
    Bindoli, A
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2002, 136 (08) : 1162 - 1168
  • [10] Phase I clinical and pharmacokinetic study of Bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    Waters, JS
    Webb, A
    Cunningham, D
    Clarke, PA
    Raynaud, F
    di Stefano, F
    Cotter, FE
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (09) : 1812 - 1823