Cellular and Humoral Responses to Leishmania major Virulence Factors in Healed Cutaneous Leishmaniasis and Mediterranean Visceral Leishmaniasis Patients

被引：6

作者：

Lakhal-Naouar, Ines ^{[1
]}

Boussoffara, Thouraya ^{[1
]}

Meddeb-Garnaoui, Amel ^{[1
]}

Ben Achour-Chenik, Yosser ^{[1
]}

Louzir, Hechmi ^{[1
]}

Chenik, Mehdi ^{[1
]}

机构：

[1] Inst Pasteur, Lab Immunopathol Vaccinol & Mol Genet, Tunis 1002, Tunisia

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 06期

关键词：

PROTECTIVE IMMUNITY; BALB/C MICE; PROTEIN; INFECTION; ANTIGEN;

D O I：

10.1128/CVI.00023-09

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase ( MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.

引用

收藏

页码：956 / 958

页数：3

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