Pattern of tau isoforms expression during development in vivo

被引：36

作者：

Bullmann, Torsten ^{[1
]}

Holzer, Max ^{[1
]}

Mori, Hiroshi ^{[2
]}

Arendt, Thomas ^{[1
]}

机构：

[1] Univ Leipzig, Paul Flechsig Inst Brain Res, Dept Cellular & Mol Mech Neurodegenerat, D-04019 Leipzig, Germany

[2] Osaka City Univ, Dept Neurosci, Grad Sch Med, Abeno Ku, Osaka 5458585, Japan

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2009年 / 27卷 / 06期

关键词：

Development; Neuronal differentiation; Neuronal plasticity; Neocortex; Cerebellum; Tubulin; MESSENGER-RNA; MICROTUBULE-BINDING; DEFICIENT MICE; PROTEIN; NEUROGENESIS; CORTEX; CELLS; NEURODEGENERATION; PHOSPHORYLATION; SYNAPTOGENESIS;

D O I：

10.1016/j.ijdevneu.2009.06.001

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Neuronal morphology and axonal growth during development are correlated to specific expression of various microtubule-associated protein tau isoforms. Using RT-PCR and Western blotting we found the unexpected result that the shift from fetal towards adult isoforms does not differ between rat cerebral cortex and cerebellum, two temporally differently developing areas. By immunohistochemistry we observed a cell type specific isoform expression during development and adulthood. The developmental expression of tau isoforms was compared to the appearance of stable microtubules assessed by the immunohistochemical detection of tubulin modifications. The tau isoform shift shows an apparent disconnect to neurogenesis, migration and volume growth, but coincides with the formation of synapses and the appearance of stable microtubules. (C) 2009 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：591 / 597

页数：7

共 32 条

[1]

AUTORADIOGRAPHIC AND HISTOLOGICAL STUDIES OF POSTNATAL NEUROGENESIS .3. DATING TIME OF PRODUCTION AND ONSET OF DIFFERENTIATION OF CEREBELLAR MICRONEURONS IN RATS [J].

ALTMAN, J .

JOURNAL OF COMPARATIVE NEUROLOGY, 1969, 136 (03) :269-&

[2]

STRUCTURE AND NOVEL EXONS OF THE HUMAN-TAU GENE [J].

ANDREADIS, A ;

BROWN, WM ;

KOSIK, KS .

BIOCHEMISTRY, 1992, 31 (43) :10626-10633

[3]

SPLICING OF JUVENILE AND ADULT TAU-MESSENGER RNA VARIANTS IS REGULATED BY THYROID-HORMONE [J].

ANIELLO, F ;

COUCHIE, D ;

BRIDOUX, AM ;

GRIPOIS, D ;

NUNEZ, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :4035-4039

[4]

INDIVIDUAL MICROTUBULES IN THE AXON CONSIST OF DOMAINS THAT DIFFER IN BOTH COMPOSITION AND STABILITY [J].

BAAS, PW ;

BLACK, MM .

JOURNAL OF CELL BIOLOGY, 1990, 111 (02) :495-509

[5]

Buée L, 1999, BRAIN PATHOL, V9, P681

[6]

Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus [J].

Bullmann, Torsten ;

de Silva, Rohan ;

Holzer, Max ;

Mori, Hiroshi ;

Arendt, Thomas .

HIPPOCAMPUS, 2007, 17 (02) :98-102

[7]

Modulation of microtubule dynamics by tau in living cells: Implications for development and neurodegeneration [J].

Bunker, JM ;

Wilson, L ;

Jordan, MA ;

Feinstein, SC .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (06) :2720-2728

[8]

INHIBITION OF NEURITE POLARITY BY TAU ANTISENSE OLIGONUCLEOTIDES IN PRIMARY CEREBELLAR NEURONS [J].

CACERES, A ;

KOSIK, KS .

NATURE, 1990, 343 (6257) :461-463

[9]

Tau mRNA isoforms following sciatic nerve axotomy with and without regeneration [J].

Chambers, CB ;

Muma, NA .

MOLECULAR BRAIN RESEARCH, 1997, 48 (01) :115-124

[10]

COUCHIE D, 1990, EXP BRAIN RES, V82, P589

← 1 2 3 4 →