Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii)

被引：24

作者：

Maiwald, M

von Herbay, A

Lepp, PW

Relman, DA

机构：

[1] VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[4] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 11期

关键词：

D O I：

10.1128/JB.182.11.3292-3297.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Whipple's disease is a systemic disorder associated with a cultivation-resistant, poorly characterized actinomycete, Tropheryma whippelii. We determined a nearly complete rRNA operon sequence of T. whippelii from specimens from 3 patients with Whipple's disease, as well as partial operon sequences from 43 patients. Variability was observed in the 16S-23S rRNA spacer sequences, leading to the description of five distinct sequence types. One specimen contained two spacer sequence types, raising the possibility of a double infection. Secondary structure models for the primary rRNA transcript and mature rRNAs revealed rare or unique features.

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页码：3292 / 3297

页数：6

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