Advances in Geroscience: Impact on Healthspan and Chronic Disease

被引：141

作者：

Burch, John B. ^{[1
]}

Augustine, Alison Deckhut ^{[2
]}

Frieden, Leslie A. ^{[3
]}

Hadley, Evan ^{[4
]}

Howcroft, T. Kevin ^{[5
]}

Johnson, Ron ^{[6
]}

Khalsa, Partap S. ^{[7
]}

Kohanski, Ronald A. ^{[8
]}

Li, Xiao Ling ^{[9
]}

Macchiarini, Francesca ^{[10
]}

Niederehe, George ^{[11
]}

Oh, Young S. ^{[12
]}

Pawlyk, Aaron C. ^{[13
]}

Rodriguez, Henry ^{[14
]}

Rowland, Julia H. ^{[15
]}

Shen, Grace L. ^{[16
]}

Sierra, Felipe ^{[8
]}

Wise, Bradley C. ^{[17
]}

机构：

[1] NIH, Ctr Sci Review, Bethesda, MD 20892 USA

[2] NIAID, Immunoregulat Sect, Basic Immunol Branch, Div Allergy Immunol & Transplantat, Bethesda, MD 20892 USA

[3] Natl Inst Dent & Craniofacial Res, Res Training & Career Dev Branch, Bethesda, MD USA

[4] NIA, Div Geriatr & Clin Gerontol, Bethesda, MD 20892 USA

[5] NCI, NIH, Div Canc Biol, Bethesda, MD 20892 USA

[6] NCI, Canc Etiol Branch, DNA & Chromosome Aberrat Branch, Div Canc Biol, Bethesda, MD 20892 USA

[7] Natl Ctr Complementary & Alternat Med, Div Extramural Res, Bethesda, MD USA

[8] NIA, Div Aging Biol, Bethesda, MD 20892 USA

[9] NIEHS, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA

[10] NIAID, Program Div Allergy Immunol & Transplantat, Bethesda, MD 20892 USA

[11] NIMH, Geriatr & Aging Proc Res Branch, Bethesda, MD 20892 USA

[12] NHLBI, Vasc Biol & Hypertens Branch, Div Cardiovasc Sci, Bethesda, MD 20892 USA

[13] NIDDK, Div Diabet Endocrinol & Metab Dis, Bethesda, MD 20892 USA

[14] NCI, Off Canc Clin Prote Res, Off Director, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[15] NCI, Off Canc Survivorship, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[16] NEI, Retinal Dis Program, Div Extramural Res, NIH, Bethesda, MD 20892 USA

[17] NIA, Neurobiol Aging Branch, Div Neurosci, Bethesda, MD 20892 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2014年 / 69卷

关键词：

Chronic disease; Geroscience;

D O I：

10.1093/gerona/glu041

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Population aging is unprecedented, without parallel in human history, and the 21st century will witness even more rapid aging than did the century just past. Improvements in public health and medicine are having a profound effect on population demographics worldwide. By 2017, there will be more people over the age of 65 than under age 5, and by 2050, two billion of the estimated nine billion people on Earth will be older than 60 (http://unfpa.org/ageingreport/). Although we can reasonably expect to live longer today than past generations did, the age-related disease burden we will have to confront has not changed. With the proportion of older people among the global population being now higher than at any time in history and still expanding, maintaining health into old age (or healthspan) has become a new and urgent frontier for modern medicine. Geroscience is a cross-disciplinary field focused on understanding the relationships between the processes of aging and age-related chronic diseases. On October 30-31, 2013, the trans-National Institutes of Health GeroScience Interest Group hosted a Summit to promote collaborations between the aging and chronic disease research communities with the goal of developing innovative strategies to improve healthspan and reduce the burden of chronic disease.

引用

页码：S1 / S3

页数：3