TP53 alterations in atypical ductal hyperplasia and ductal carcinoma in situ of the breast

被引：22

作者：

Chitemerere, M

Andersen, TI

Holm, R

Karlsen, F

Borresen, AL

Nesland, JM

机构：

[1] NORWEGIAN RADIUM HOSP,DEPT PATHOL,N-0310 OSLO,NORWAY

[2] INST CANC RES,N-0310 OSLO,NORWAY

[3] NORWEGIAN RADIUM HOSP,DEPT GENET,N-0310 OSLO,NORWAY

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1996年 / 41卷 / 02期

关键词：

atypical ductal hyperplasia; DCIS; p53; tumor development; tumor suppressor genes;

D O I：

10.1007/BF01807155

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormalities in the TP53 tumour suppressor gene in 75 atypical ductal hyperplasias and 62 ductal-carcinomas in situ (DCIS) of the breast were studied using immunohistochemistry and mutation analysis, Accumulation of p53 protein was detected in 10 out of 62 (16%) DCIS, whereas no cases of positive staining was observed in the atypical lesions. TP53 mutations were identified in four out of 30 (13%) DCIS by constant denaturant gel electrophoresis (CDGE). Two of these cases were positive and two negative for p53 protein. A total of 12 out of 62 DCIS (19%) carried TP53 mutation and/or p53 protein overexpression. The present results suggest that TP53 alterations may be important in the development of a subset of DCIS.

引用

页码：103 / 109

页数：7

共 37 条

[1] ANDERSEN TI, 1993, BRIT J CANCER, V68, P560
[2] ANDERSEN TI, IN PRESS DIAGN MOL P
[3] [Anonymous], MAJOR PROBLEMS PATHO
[4] PATTERNS OF EXPRESSION OF THE P53 TUMOR SUPPRESSOR IN HUMAN BREAST TISSUES AND TUMORS INSITU AND INVITRO
BARTEK, J
BARTKOVA, J
VOJTESEK, B
STASKOVA, Z
REJTHAR, A
KOVARIK, J
LANE, DP
[J]. INTERNATIONAL JOURNAL OF CANCER, 1990, 46 (05) : 839 - 844
[5] BHARGAVA V, 1994, MODERN PATHOL, V7, P361
[6] BOBROW LG, 1994, SEMIN DIAGN PATHOL, V11, P199
[7] CONSTANT DENATURANT GEL-ELECTROPHORESIS AS A RAPID SCREENING TECHNIQUE FOR P53 MUTATIONS
BORRESEN, AL
HOVIG, E
SMITHSORENSEN, B
MALKIN, D
LYSTAD, S
ANDERSEN, TI
NESLAND, JM
ISSELBACHER, KJ
FRIEND, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) : 8405 - 8409
[8] TP53 MUTATIONS AND BREAST-CANCER PROGNOSIS - PARTICULARLY POOR SURVIVAL RATES FOR CASES WITH MUTATIONS IN THE ZINC-BINDING DOMAINS
BORRESEN, AL
ANDERSEN, TI
EYFJORD, JE
CORNELIS, RS
THORLACIUS, S
BORG, A
JOHANSSON, U
THEILLET, C
SCHERNECK, S
HARTMAN, S
CORNELISSE, CJ
HOVIG, E
DEVILEE, P
[J]. GENES CHROMOSOMES & CANCER, 1995, 14 (01) : 71 - 75
[9] COLES C, 1992, CANCER RES, V52, P5291
[10] DETECTION OF POINT MUTATIONS IN THE P53 GENE - COMPARISON OF SINGLE-STRAND CONFORMATION POLYMORPHISM, CONSTANT DENATURANT GEL-ELECTROPHORESIS, AND HYDROXYLAMINE AND OSMIUM-TETROXIDE TECHNIQUES
CONDIE, A
EELES, R
BORRESEN, AL
COLES, C
COOPER, C
PROSSER, J
[J]. HUMAN MUTATION, 1993, 2 (01) : 58 - 66

← 1 2 3 4 →