Neutrophil Extracellular Trap in Human Diseases

被引：25

作者：

Arazna, Magdalena ^{[1
]}

Pruchniak, Michal P. ^{[1
]}

Zycinska, Katarzyna ^{[2
]}

Demkow, Urszula ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Lab Diagnost, Clin Immunol Dev Age, PL-00576 Warsaw, Poland

[2] Med Univ Warsaw, Dept Family Med Internal & Metab Dis, Syst Vasc Outpatient Clin, Warsaw, Poland

来源：

RESPIRATORY REGULATION - THE MOLECULAR APPROACH | 2013年 / 756卷

关键词：

NETosis; Neutrophil extracellular trap; Autoimmune disease; Immunity; Neoplasms; NETTING NEUTROPHILS; ASSOCIATION; MOLECULES; INFECTION; DAMAGE;

D O I：

10.1007/978-94-007-4549-0_1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill microorganisms. Recently, novel functions of NET have been proposed. It seems that neutrophil traps play an essential role during autoimmunity. They can induce and exacerbate diseases based on immune system malfunction.

引用

页码：1 / 8

页数：8

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