Peptide delivery systems

被引：14

作者：

Ali, M ^{[1
]}

Manolios, N ^{[1
]}

机构：

[1] Westmead Hosp, Dept Rheumatol, Sydney, NSW, Australia

来源：

LETTERS IN PEPTIDE SCIENCE | 2001年 / 8卷 / 3-5期

关键词：

delivery system; lipopeptide; liposaccharide; liposome; peptide; polyethylene glycol;

D O I：

10.1023/A:1016277622317

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Efficient delivery of peptide drugs to the desired site is very important. There are a number of barriers that may limit using peptides as potential drugs, some of these obstacles include poor biomembrane permeability, enzymatic degradation and low pH. To improve peptide drug efficiency a selective drug delivery system is required. Here we review some of the delivery systems available for peptides and we will also briefly discuss peptides that have been used as delivery systems.

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收藏

页码：289 / 294

页数：6

相关论文

共 30 条

[1]

An antigenic HIV-1 peptide sequence engineered into the surface structure of transferrin does not elicit an antibody response [J].

Ali, SA ;

Joao, HC ;

Hammerschmid, F ;

Eder, J ;

Steinkasserer, A .

FEBS LETTERS, 1999, 459 (02) :230-232

[2]

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[3]

Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation [J].

Babu, JS ;

Nair, S ;

Kanda, P ;

Rouse, BT .

VACCINE, 1995, 13 (17) :1669-1676

[4]

The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy [J].

Bechinger, B .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1462 (1-2) :157-183

[5]

Chitosan and its derivatives:: potential excipients for peroral peptide delivery systems [J].

Bernkop-Schnürch, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 194 (01) :1-13

[6]

Synthesis by chemoselective ligation and biological evaluation of novel cell-permeable PKC-ζ pseudosubstrate lipopeptides [J].

Bonnet, D ;

Thiam, K ;

Loing, E ;

Melnyk, O ;

Gras-Masse, H .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (03) :468-471

[7]

BUNDGAARD H, 1982, OPTIMISATION DRUG DE, P351

[8]

Novel liposaccharide conjugates for drug and peptide delivery [J].

Drouillat, B ;

Hillery, AM ;

Dekany, G ;

Falconer, R ;

Wright, K ;

Toth, I .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (01) :25-30

[9]

The covalent coupling of Arg-Gly-Asp-containing peptides to liposomes: Purification and biochemical function of the lipopeptide [J].

Gyongyossy-Issa, MIC ;

Muller, W ;

Devine, DV .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 353 (01) :101-108

[10]

IMPROVEMENT OF LARGE INTESTINAL-ABSORPTION OF INSULIN BY CHEMICAL MODIFICATION WITH PALMITIC ACID IN RATS [J].

HASHIZUME, M ;

DOUEN, T ;

MURAKAMI, M ;

YAMAMOTO, A ;

TAKADA, K ;

MURANISHI, S .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1992, 44 (07) :555-559