Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

被引：111

作者：

Lee, DG

Park, Y

Kim, MR

Jung, HJ

Seu, YB

Hahm, KS

Woo, ER ^{[1
]}

机构：

[1] Chosun Univ, Res Ctr Prot Mat, Kwangju 501759, South Korea

[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

[3] Kyungpook Natl Univ, Dept Microbiol, Taegu 702701, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2004年 / 26卷 / 14期

关键词：

anti-fungal activity; trans-N-caffeoyltyramine; dihydro-N-caffeoyltyramine; trans-N-feruloyloctopamine; Lycium chinense; Solanaceae;

D O I：

10.1023/B:BILE.0000035483.85790.f7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four phenolic amides, dihydro-N-caffeoyltyramine ( 1), trans-N-feruloyloctopamine ( 2), trans-N-caffeoyltyramine ( 3), and cis-N-caffeoyltyramine ( 4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 mug ml(-1) and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 mug ml(-1). All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

引用

页码：1125 / 1130

页数：6

共 21 条

[1] DESIGN OF MODEL AMPHIPATHIC PEPTIDES HAVING POTENT ANTIMICROBIAL ACTIVITIES [J].