Pd(OAc)2-catalyzed Domino reactions of 1-chloro-2-haloarenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes

被引:33
作者
Dong, Cheng-Guo [1 ]
Hu, Qiao-Sheng
机构
[1] CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY 10314 USA
[2] CUNY Coll Staten Isl, Grad Ctr, Staten Isl, NY 10314 USA
关键词
C-H ACTIVATION; HIGHLY EFFICIENT ROUTE; TANDEM REACTIONS; CATALYZED ANNULATION; METHOXY GROUPS; ARYL; VERSATILE; BENZYNES; COCYCLOTRIMERIZATION; CARBOSTANNYLATION;
D O I
10.1021/ol061989i
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The palladium-associated aryne generation strategy and Pd(OAc)(2)-catalyzed annulative Domino reactions of 1-chloro-2-halobenzenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes are described. The palladium-associated aryne generation strategy described here not only allows the high yield, one-step access to potentially useful substituted fluorenes from readily available 1-chloro-2-halobenzenes and 2-haloaryl tosylates, but may also lead to the development of other tandem reactions based on these readily available ortho leaving group bearing haloarenes.
引用
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页码:5057 / 5060
页数:4
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