Respiratory Disorders and Hospitalization Rates During the Second RSV Season in Preterm Infants Who Received Palivizumab Prophylaxis During Their First RSV Season

被引：5

作者：

Fanos, V. ^{[2
]}

Scarcella, A. ^{[3
]}

Puddu, M. ^{[2
]}

Gallini, F. ^{[4
]}

Tuminelli, F. ^{[5
]}

Bragetti, P. ^{[6
]}

Gallina, M. R. ^{[7
]}

Quartulli, L. ^{[8
]}

Benincori, N. ^{[9
]}

Citro, G. ^{[10
]}

Via, L. Dalla ^{[11
]}

Barera, G. ^{[12
]}

Paparatti, U. Di Luzio ^{[13
]}

Merolla, R. ^{[13
]}

Romano, G. V. ^{[13
]}

Guida, G. ^{[13
]}

Silvestri, M. ^{[1
]}

Rossi, G. A. ^{[1
]}

机构：

[1] G Gaslini Inst Children, Pulm Dis Unit, I-16147 Genoa, Italy

[2] Univ Cagliari, Neonatal Intens Care Unit, Cagliari, Italy

[3] Univ Naples Federico II, Dept Pediat, Naples, Italy

[4] Univ Cattolica Sacro Cuore, Dept Neonatol, I-00168 Rome, Italy

[5] Umberto I Hosp, Div Neonatol, Enna, Italy

[6] Monteluce Policlin, Dept Gynecol Obstet & Pediat, Perugia, Italy

[7] Maggiore Carita Hosp, Dept Pediat, Novara, Italy

[8] Perrino Hosp, Div Neonatol, Brindisi, Italy

[9] GB Grassi Hosp, Div Pediat, Rome, Italy

[10] Umberto I Hosp, Neonatal Intens Care Unit, Nocera, Italy

[11] Thiene Hosp, Div Pediat, Thiene, Italy

[12] Univ Vita Salute San Raffaele, Div Pediat & Neonatol, Milan, Italy

[13] Abbott Italy, Latina, Italy

来源：

JOURNAL OF CHEMOTHERAPY | 2009年 / 21卷 / 03期

关键词：

Respiratory syncytial virus; palivizumab; recurrent wheezing; hospitalization; RSV; SYNCYTIAL VIRUS-INFECTION; REACTIVE AIRWAY DISEASE; YOUNG-CHILDREN; AGE; REHOSPITALIZATION; BRONCHIOLITIS; ALLERGY; WHEEZE; ASTHMA; RISK;

D O I：

10.1179/joc.2009.21.3.302

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This prospective study evaluated the frequency and severity of respiratory symptoms during the second respiratory syncytial virus (RSV) season in an Italian cohort of preterm infants (:535 weeks) who had received palivizumab prophylaxis in their first year of life (October 2004-April 2005) and who had not previously been hospitalized for RSV-induced lower respiratory tract infection (LRTI). Infants were evaluated at enrolment (May-September 2005), in October/November 2005 and in April 2006. The occurrence of any respiratory episode, the rate of hospitalization for respiratory-related LRTI, total length of stay in hospital, physician-documented recurrent wheezing (23 physician-documented episodes of wheezing) and use of airway medication/antibiotics were recorded during follow-up. All infants had prior palivizumab prophylaxis during their first RSV season. In the total evaluable population (n=260), 32.3% of infants experienced at least one respiratory episode, 3.8% required short hospitalization because of LRTI, 8.5% had physician-documented recurrent wheezing, and 48.8% required airway medications/antibiotics during follow-up. In this study the rate of airway morbidity, hospitalization and physician-documented recurrent wheezing during the second RSV season was low among preterm infants who had received prior palivizumab prophylaxis.

引用

页码：302 / 310

页数：9

共 24 条

[1]

Seasonality of long term wheezing following respiratory syncytial virus lower respiratory tract infection [J].