Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease

被引:370
作者
Ananthakrishnan, Ashwin N. [1 ,2 ]
Khalili, Hamed [1 ,2 ]
Konijeti, Gauree G. [1 ,2 ]
Higuchi, Leslie M. [2 ,3 ]
de Silva, Punyanganie [1 ,2 ]
Fuchs, Charles S. [2 ,4 ,5 ]
Willett, Walter C. [2 ,5 ,6 ]
Richter, James M. [1 ,2 ]
Chan, Andrew T. [1 ,2 ,5 ]
机构
[1] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Childrens Hosp Boston, Div Gastroenterol & Nutr, Boston, MA USA
[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[5] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA
[6] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
INFLAMMATORY-BOWEL-DISEASE; RANDOMIZED CONTROLLED-TRIALS; EUROPEAN PROSPECTIVE COHORT; SUDDEN CARDIAC DEATH; ADIPOSE-TISSUE; LINOLEIC-ACID; SYSTEMIC INFLAMMATION; ADHESION MOLECULES; US WOMEN; FISH-OIL;
D O I
10.1136/gutjnl-2013-305304
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Introduction Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited and conflicting. Methods We conducted a prospective study of women enrolled in the Nurses' Health Study cohorts. Diet was prospectively ascertained every 4 years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake and specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders. Results Among 170 805 women, we confirmed 269 incident cases of CD (incidence 8/100 000 person-years) and 338 incident cases of UC (incidence 10/100 000 person-years) over 26 years and 3 317 338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFAs) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFAs was associated with a trend towards lower risk of UC (HR 0.72, 95% CI 0.51 to 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 to 1.92). Conclusions A high intake of dietary long-chain n-3 PUFAs may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC.
引用
收藏
页码:776 / 784
页数:9
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