Lhx2 maintains stem cell character in hair follicles

被引：268

作者：

Rhee, Horace ^{[1
]}

Polak, Lisa ^{[1
]}

Fuchs, Elaine ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

SCIENCE | 2006年 / 312卷 / 5782期

关键词：

D O I：

10.1126/science.1128004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During embryogenesis, stem cells are set aside to fuel the postnatal hair cycle and repair the epidermis after injury. To define how hair follicle stem cells are specified and maintained in an undifferentiated state, we developed a strategy to isolate and transcriptionally profile embryonic hair progenitors in mice. We identified Lhx2 as a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but upstream from signals required to drive activated stem cells to terminally differentiate. Using gain- and loss-of-function studies, we uncovered a rote for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors.

引用

页码：1946 / 1949

页数：4

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