Age-related left ventricular function in the mouse: analysis based on in vivo pressure-volume relationships

被引:103
作者
Yang, B
Larson, DF [1 ]
Watson, R
机构
[1] Univ Arizona, Dept Surg, Tucson, AZ 85724 USA
[2] Univ Arizona, Ctr Heart, Tucson, AZ 85721 USA
[3] Arizona Prevent Ctr, Tucson, AZ USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1999年 / 277卷 / 05期
关键词
senescence; conductance catheter; end-systolic pressure-volume relationship; preload recruitable stroke work;
D O I
10.1152/ajpheart.1999.277.5.H1906
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our study compared left ventricular (LV) function between senescent and young adult mice through in situ pressure-volume loop analysis. Two groups of mice (n = 9 each), B-mo-old and 16-mo-old (senescent) mice, were anesthetized with urethan and a-chloralose, and their LV were instrumented with a Millar 1.4-Fr conductance micromanometer catheter for the acquisition of the pressure-volume loops. The senescent mice had a significantly decreased contractile function related to load-dependent parameters, including stroke volume index, ejection fraction, cardiac output index, stroke work index, and maximum derivative of change in systolic pressure over time. The load-independent parameters, preload recruitable stroke work and the slope tend-systolic volume elastance) of the end-systolic pressure-volume relationship, were significantly decreased in the senescent mice. Heart rate and arterial elastance were not different between the two groups; however, the ventricular-to-vascular coupling ratio (ratio of elastance of artery to end-systolic volume elastance) was increased by threefold in the senescent mice (P < 0.001). Thus there were significant decreases in contractile function in the senescent mouse heart that appeared to be related to reduced mechanical efficiency but not related to arterial elastance.
引用
收藏
页码:H1906 / H1913
页数:8
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