Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity

被引：61

作者：

Wang, Sicen ^{[1
]}

Wen, Binyu ^{[1
]}

Wang, Na ^{[1
]}

Liu, Juntian ^{[1
]}

He, Langchong ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Med, Xian 710061, Shaanxi, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 04期

关键词：

Caulophyllum robustum Maxim; Caulophine; Anti-myocardial ischemia; TASPINE;

D O I：

10.1007/s12272-009-1407-7

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.

引用

页码：521 / 526

页数：6

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