Effect of age on cerebrospinal fluid levels of metabolites of biopterin and biogenic amines

被引：10

作者：

Komori, H

Matsuishi, T ^{[1
]}

Yamada, S

Ueda, N

Yamashita, Y

Kato, H

机构：

[1] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Kurume, Fukuoka 830, Japan

[2] Kurume Univ, Sch Med, Inst Res Brain Dis, Kurume, Fukuoka 830, Japan

[3] Kurume Univ, Sch Med, Dept Anesthesiol, Kurume, Fukuoka 830, Japan

来源：

ACTA PAEDIATRICA | 1999年 / 88卷 / 12期

关键词：

biopterin; cerebrospinal fluid; 5-hydroxyindoleacetic acid; homovanillic acid; tetrahydrobiopterin;

D O I：

10.1080/080352599750030059

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We identified an age effect on biopterin and biogenic amine metabolites in the cerebrospinal fluid from 56 neurologically normal patients, aged 1 mo to 80 y. The levels of total and reduced forms of biopterin, homovanillic acid, and 5-hydroxyindoleacetic acid were found to peak during the first year of life. The levels of these metabolites then gradually decreased, plateauing at the age of 20y. We found significant correlations between biopterin, homovanillic acid, and 5-hydroxyindoleacetic acid.

引用

收藏

页码：1344 / 1347

页数：4

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