Contributions of Fas-Fas ligand: Interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

被引：55

作者：

Parra, B

Lin, MT

Stohlman, SA

Bergmann, CC

Atkinson, R

Hinton, DR

机构：

[1] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

[3] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 05期

关键词：

D O I：

10.1128/JVI.74.5.2447-2450.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

引用

收藏

页码：2447 / 2450

页数：4

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