Synthesis of transition state inhibitors for N-riboside hydrolases and transferases

被引:77
作者
Furneaux, RH
Limberg, G
Tyler, PC
Schramm, VL
机构
[1] IND RES LTD,LOWER HUTT,NEW ZEALAND
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT BIOCHEM,BRONX,NY 10461
关键词
D O I
10.1016/S0040-4020(96)01172-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is the condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:2915 / 2930
页数:16
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