Study on acetylcholinesterase inhibition induced by endogenous neurotoxin with an enzyme-semiconductor photoelectrochemical system

被引：34

作者：

Zhu, Wei ^{[1
]}

An, Ya-Rui ^{[1
]}

Luo, Xiao-Min ^{[2
,3
,4
]}

Wang, Fei ^{[2
,3
,4
]}

Zheng, Jiao-Hong ^{[1
]}

Tang, Lin-Lin ^{[1
]}

Wang, Qing-Jiang ^{[1
]}

Zhang, Zhong-Hai ^{[1
]}

Zhang, Wen ^{[1
]}

Jin, Li-Tong ^{[1
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

[2] Chinese Acad Sci, Ctr Drug Discovery & Design, Shanghai 201203, Peoples R China

[3] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Met Med, Shanghai 201203, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 19期

关键词：

PARKINSONS-DISEASE; QUANTUM DOTS; GOLD NANOPARTICLES; DOPAMINE; N-METHYL-(R)-SALSOLINOL; ELECTRODE; DEMENTIA; BALANCE; BRAIN; TIO2;

D O I：

10.1039/b900623k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The integration of Au-doped TiO2 nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO2 hybrid system, which provides a new rapid and valid photo-electrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin.

引用

页码：2682 / 2684

页数：3

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