Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

被引：921

作者：

Wiertz, EJHJ

Tortorella, D

Bogyo, M

Yu, J

Mothes, W

Jones, TR

Rapoport, TA

Ploegh, HL

机构：

[1] MIT, CTR CANC RES, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[2] HARVARD UNIV, SCH MED, DEPT CELL BIOL, BOSTON, MA 02115 USA

[3] WYETH AYERST RES, INFECT DIS SECT, DEPT MOL BIOL, PEARL RIVER, NY 10965 USA

来源：

NATURE | 1996年 / 384卷 / 6608期

关键词：

D O I：

10.1038/384432a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

引用

页码：432 / 438

页数：7

共 50 条

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[2]

BEERSMA MFC, 1993, J IMMUNOL, V151, P4455

[3] Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway [J].