Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy

被引：112

作者：

Stein, Erich W. ^{[1
]}

Maslov, Konstantin ^{[1
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Opt Imaging Lab, Dept Biomed Engn, St Louis, MO 63130 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2009年 / 14卷 / 02期

关键词：

Photoacoustic imaging; photoacoustic microscopy; functional brain imaging; neuroimaging; noninvasive imaging; somatosensory cortex; hemodynamics; FMRI;

D O I：

10.1117/1.3095799

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photoacoustic microscopy (PAM) has been used to obtain high-resolution, noninvasive images of the in vivo mouse brain. In this work, we exploit the high-depth and temporal resolutions of PAM to noninvasively image the blood-oxygenation dynamics of multiple cortex vessels in the mouse brain simultaneously in response to controlled hypoxic and hyperoxic challenges. These results confirm the ability of PAM to track blood oxygenation in the mouse brain, a critical aspect of imaging brain activity through the hemodynamic response. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3095799]

引用

页数：3

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