Nitrotyrosine-modified SERCA2: a cellular sensor of reactive nitrogen species

被引：23

作者：

Bigelow, Diana J. ^{[1
]}

机构：

[1] Pacific NW Natl Lab, Div Biol, Richland, WA 99352 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 457卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SERCA2; Aging; Oxidation; Inflammation; Reactive oxygen species; Nitrotyrosine; NITRIC-OXIDE SYNTHASE; SARCOPLASMIC-RETICULUM CA2+-ATPASE; PROTEIN-TYROSINE NITRATION; SKELETAL-MUSCLE; S-GLUTATHIOLATION; CALCIUM-ATPASE; CA-ATPASE; CONTRACTILE DYSFUNCTION; BIOLOGICAL IMPLICATIONS; SELECTIVE DEGRADATION;

D O I：

10.1007/s00424-007-0429-6

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

The endo-/sarcoplasmic reticulum Ca2+-Mg2+-adenosine triphosphatase (SERCA2) isoform of the sarco/endoplasmic reticulum Ca2+-ATPase is sensitive to cellular conditions of inflammation and oxidative stress as evidenced by the common appearance of 3-nitrotyrosine-modified forms of SERCA2 in aging and disease in both striated and smooth muscle of humans and rodent models. Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr(294) and Tyr(295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca2+-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species. This review discusses recent work regarding the nitrative and oxidative sensitivity of SERCA2 in muscle with respect to general cellular mechanisms of turnover and repair of modified proteins.

引用

页码：701 / 710

页数：10

共 67 条

[1]

S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide [J].

Adachi, T ;

Weisbrod, RM ;

Pimentel, DR ;

Ying, J ;

Sharov, VS ;

Schöneich, C ;

Cohen, RA .

NATURE MEDICINE, 2004, 10 (11) :1200-1207

[2]

Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca2+-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation [J].

Adachi, T ;

Matsui, R ;

Xu, SQ ;

Kirber, M ;

Lazar, HL ;

Sharov, VS ;

Schöneich, C ;

Cohen, RA .

CIRCULATION RESEARCH, 2002, 90 (10) :1114-1121

[3]

Selective NOS inhibition restores myocardial contractility in endotoxemic rats; However, myocardial NO content does not correlate with myocardial dysfunction [J].

Afulukwe, IF ;

Cohen, RI ;

Zeballos, GA ;

Iqbal, M ;

Scharf, SM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (01) :21-26

[4]

Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells [J].

Andrienko, T ;

Kuznetsov, AV ;

Kaambre, T ;

Usson, Y ;

Orosco, A ;

Appaix, F ;

Tiivel, T ;

Sikk, P ;

Vendelin, M ;

Margreiter, R ;

Saks, VA .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2003, 206 (12) :2059-2072

[5]

A quantitative and validated SAGE transcriptome reference for adult mouse heart [J].

Anisimov, SV ;

Tarasov, KV ;

Stern, MD ;

Lakatta, EG ;

Boheler, KR .

GENOMICS, 2002, 80 (02) :213-222

[6]

Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria [J].

Appaix, F ;

Kuznetsov, AV ;

Usson, Y ;

Kay, L ;

Andrienko, T ;

Olivares, J ;

Kaambre, T ;

Sikk, P ;

Margreiter, R ;

Saks, V .

EXPERIMENTAL PHYSIOLOGY, 2003, 88 (01) :175-190

[7]

Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine [J].

Balabanli, B ;

Kamisaki, Y ;

Martin, E ;

Murad, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) :13136-13141

[8]

Protein tyrosine nitration in the ventilatory muscles - Role of nitric oxide synthases [J].

Barreiro, E ;

Comtois, AS ;

Gea, J ;

Laubach, VE ;

Hussain, SNA .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 26 (04) :438-446

[9]

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase [J].

Batkai, Sandor ;

Rajesh, Mohanraj ;

Mukhopadhyay, Partha ;

Hasko, Gyorgy ;

Liaudet, Lucas ;

Cravatt, Benjamin F. ;

Csiszar, Anna ;

Ungvari, Zoltan ;

Pacher, Pal .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (02) :H909-H918

[10]

The versatility and universality of calcium signalling [J].

Berridge, MJ ;

Lipp, P ;

Bootman, MD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21

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