ADD-1 provides major new insight into the mechanism of insulin action

被引：30

作者：

Flier, JS

Hollenberg, AN

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol & Metab, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 25期

关键词：

D O I：

10.1073/pnas.96.25.14191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：14191 / 14192

页数：2

共 14 条

[1]

Brown MS, 1998, NUTR REV, V56, pS1

[2]

Fajas L, 1999, MOL CELL BIOL, V19, P5495

[3] Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes [J].

Foretz, M ;

Guichard, C ;

Ferré, P ;

Foufelle, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12737-12742

[4]

Foretz M, 1999, MOL CELL BIOL, V19, P3760

[5] ADD1/SREBP1 activates PPARγ through the production of endogenous ligand [J].

Kim, JB ;

Wright, HM ;

Wright, M ;

Spiegelman, BM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4333-4337

[6] ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism [J].

Kim, JB ;

Spiegelman, BM .

GENES & DEVELOPMENT, 1996, 10 (09) :1096-1107

[7] Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 [J].

Kim, JB ;

Sarraf, P ;

Wright, M ;

Yao, KM ;

Mueller, E ;

Solanes, G ;

Lowell, BB ;

Spiegelman, BM .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (01) :1-9

[8] Regulation of gene expression by insulin [J].

OBrien, RM ;

Granner, DK .

PHYSIOLOGICAL REVIEWS, 1996, 76 (04) :1109-1161

[9] Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a [J].

Shimano, H ;

Horton, JD ;

Hammer, RE ;

Shimomura, I ;

Brown, MS ;

Goldstein, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (07) :1575-1584

[10] Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes [J].

Shimomura, L ;

Bashmakov, Y ;

Ikemoto, S ;

Horton, JD ;

Brown, MS ;

Goldstein, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :13656-13661

← 1 2 →