Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs

被引：27

作者：

Schaller, A ^{[1
]}

Sun, ZH ^{[1
]}

Yang, YP ^{[1
]}

Somoskovi, A ^{[1
]}

Zhang, Y ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2636-2639.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as shown with a tetrazolium redox dye viability assay and a bacterial survival assay. Salicylate-induced resistance was more pronounced for PAS, STR, and EMB but was not apparent for INH and RMP when salicylate and the anti-TB agents were incorporated into 7H11 plates. The significance of these findings for TB treatment needs to be further evaluated in vivo.

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收藏

页码：2636 / 2639

页数：4

相关论文

共 12 条

[1] The effect of salicylate on the oxygen uptake of the tubercle bacillus [J].

Bernheim, Frederick .

SCIENCE, 1940, 92 (2383) :204-204

[2] SALICYLATE INDUCTION OF ANTIBIOTIC-RESISTANCE IN ESCHERICHIA-COLI - ACTIVATION OF THE MAR OPERON AND A MAR-INDEPENDENT PATHWAY [J].

COHEN, SP ;

LEVY, SB ;

FOULDS, J ;

ROSNER, JL .

JOURNAL OF BACTERIOLOGY, 1993, 175 (24) :7856-7862

[3] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[4] Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus [J].

Gustafson, JE ;

Candelaria, PV ;

Fisher, SA ;

Goodridge, JP ;

Lichocik, TM ;

McWilliams, TM ;

Price, CTD ;

O'Brien, FG ;

Grubb, WB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (04) :990-992

[5]

LEHMANN J, 1946, LANCET, V250, P14

[6] Multidrug resistance following expression of the Escherichia coli marA gene in Mycobacterium smegmatis [J].

McDermott, PF ;

White, DG ;

Podglajen, I ;

Alekshun, MN ;

Levy, SB .

JOURNAL OF BACTERIOLOGY, 1998, 180 (11) :2995-2998

[7] AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants [J].

Okusu, H ;

Ma, D ;

Nikaido, H .

JOURNAL OF BACTERIOLOGY, 1996, 178 (01) :306-308

[8]

PLOTZ PH, 1985, TXB RHEUMATOLOGY, V2

[9] The effects of salicylate on bacteria [J].

Price, CTD ;

Lee, IR ;

Gustafson, JE .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2000, 32 (10) :1029-1043

[10] NONHERITABLE RESISTANCE TO CHLORAMPHENICOL AND OTHER ANTIBIOTICS INDUCED BY SALICYLATES AND OTHER CHEMOTACTIC REPELLENTS IN ESCHERICHIA-COLI K-12 [J].

ROSNER, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8771-8774