Increased CD38 expression is associated with favorable prognosis in adult acute leukemia

被引：71

作者：

Keyhani, A

Huh, YO

Jendiroba, D

Pagliaro, L

Cortez, J

Pierce, S

Pearlman, M

Estey, E

Kantarjian, H

Freireich, EJ

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Lab Med, Houston, TX 77030 USA

来源：

LEUKEMIA RESEARCH | 2000年 / 24卷 / 02期

关键词：

CD38; acute leukemia; prognosis; survival; clinical outcome;

D O I：

10.1016/S0145-2126(99)00147-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD38 is expressed in acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) blasts and its prognostic significance is unknown. We investigated CD38 expression in 304 AML and 138 ALL patients. CD38 was lower in AML-M3 compared to other FAB subtypes (5% vs. 41%; P < 0.001), but was similar among ALL subtypes (56.6%; P = 0.69). Ph + ALL and AML with t(15;17) patients showed lower CD38 expression than the other cytogenetic groups. Overall survival favored AML and ALL patients with higher CD38 levels. Multivariate analysis revealed CD38 expression to be an independent outcome predictor in AML, but not in ALL. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：153 / 159

页数：7

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