Utilising molecular biological and histopathological techniques to study the dopaminergic system in patients with melancholia

被引:7
作者
Hickie, I
Lloyd, A
Dixon, G
Halliday, G
McRitchie, D
Scott, E
Mitchell, P
Wakefield, D
机构
[1] UNIV NEW S WALES, SCH PATHOL, INFLAMMAT RES UNIT, SYDNEY, NSW, AUSTRALIA
[2] PRINCE WALES MED RES INST, SYDNEY, NSW, AUSTRALIA
[3] PRINCE HENRY HOSP, MOOD DISORDERS UNIT, SYDNEY, NSW, AUSTRALIA
[4] UNIV NEW S WALES, SCH PSYCHIAT, SYDNEY, NSW, AUSTRALIA
关键词
dopamine; in situ hybridisation; melancholia;
D O I
10.3109/00048679709073796
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To describe the rationale for investigating the dopaminergic system in patients with melancholia by applying molecular biological (notably, in situ hybridisation) and histopathological techniques in postmortem brain tissue. Method: Relevant advances in the functional neuroanatomy of frontostriatal circuits, as well as insights from clinical neuroimaging studies in primary and secondary depressive disorders, are presented, These are integrated with developments in the pharmacological and molecular characteristics of dopamine receptor subtypes and recognition of their selective anatomical distribution. Results: Converging data from the basic and clinical neurosciences suggest that the pathophysiology of depressive disorders characterised by psychomotor phenomena, such as melancholia, may involve dysregulation of dopaminergic mechanisms within complex frontostriatal circuits. Conclusions: The key feature of in situ hybridisation is its capacity to test for variations in the functional components of designated biochemical systems within highly specific anatomical regions. We utilise this approach, in combination with relevant histopathological techniques, to test the structural and functional integrity of the dopaminergic system within key fronto-striatal circuits in patients who had exhibited psychomotor phenomena, The same approach can also be used to study the integrity of other relevant biochemical systems, such as the serotoninergic and noradrenergic systems, in patients with other mood disorders.
引用
收藏
页码:27 / 35
页数:9
相关论文
共 36 条
  • [1] ALEXANDER GE, 1990, PROG BRAIN RES, V85, P119
  • [2] THE ANATOMY OF MELANCHOLIA - DOES FRONTAL-SUBCORTICAL PATHOPHYSIOLOGY UNDERPIN ITS PSYCHOMOTOR AND COGNITIVE MANIFESTATIONS
    AUSTIN, MP
    MITCHELL, P
    [J]. PSYCHOLOGICAL MEDICINE, 1995, 25 (04) : 665 - 672
  • [3] PARKINSONIAN-LIKE LOCOMOTOR IMPAIRMENT IN MICE LACKING DOPAMINE D2 RECEPTORS
    BAIK, JH
    PICETTI, R
    SAIARDI, A
    THIRIET, G
    DIERICH, A
    DEPAULIS, A
    LEMEUR, M
    BORRELLI, E
    [J]. NATURE, 1995, 377 (6548) : 424 - 428
  • [4] REGIONAL CEREBRAL BLOOD-FLOW IN DEPRESSION MEASURED BY POSITRON EMISSION TOMOGRAPHY - THE RELATIONSHIP WITH CLINICAL DIMENSIONS
    BENCH, CJ
    FRISTON, KJ
    BROWN, RG
    FRACKOWIAK, RSJ
    DOLAN, RJ
    [J]. PSYCHOLOGICAL MEDICINE, 1993, 23 (03) : 579 - 590
  • [5] AKINESIA - A SYNDROME COMMON TO PARKINSONISM, RETARDED DEPRESSION, AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA
    BERMANZOHN, PC
    SIRIS, SG
    [J]. COMPREHENSIVE PSYCHIATRY, 1992, 33 (04) : 221 - 232
  • [6] Carroll BJ, 1991, PSYCHOPATHOLOGY BRAI
  • [7] COFFEY CE, 1993, ARCH GEN PSYCHIAT, V50, P7
  • [8] COFFEY CE, 1990, AM J PSYCHIAT, V147, P187
  • [9] CUMMINGS JL, 1992, AM J PSYCHIAT, V149, P443
  • [10] PSYCHOLOGICAL DYSFUNCTION ACCOMPANYING SUBCORTICAL DEMENTIAS
    CUMMINGS, JL
    BENSON, DF
    [J]. ANNUAL REVIEW OF MEDICINE, 1988, 39 : 53 - 61