Intranuclear inclusions and the ubiquitin-proteasome pathway: Digestion of a red herring?

被引:12
作者
Floyd, JA [1 ]
Hamilton, BA
机构
[1] Univ Calif San Diego, Biomed Sci Grad Program, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
关键词
D O I
10.1016/S0896-6273(00)81022-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:765 / 766
页数:2
相关论文
共 11 条
[1]   Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice [J].
Cummings, CJ ;
Reinstein, E ;
Sun, YL ;
Antalffy, B ;
Jiang, YH ;
Ciechanover, A ;
Orr, HT ;
Beaudet, AL ;
Zoghbi, HY .
NEURON, 1999, 24 (04) :879-892
[2]   TRANSCRIPTIONAL ACTIVATION MODULATED BY HOMOPOLYMERIC GLUTAMINE AND PROLINE STRETCHES [J].
GERBER, HP ;
SEIPEL, K ;
GEORGIEV, O ;
HOFFERER, M ;
HUG, M ;
RUSCONI, S ;
SCHAFFNER, W .
SCIENCE, 1994, 263 (5148) :808-811
[3]  
Huynh DP, 1999, ANN NEUROL, V45, P232, DOI 10.1002/1531-8249(199902)45:2<232::AID-ANA14>3.0.CO
[4]  
2-7
[5]   Mutation of the angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation [J].
Jiang, YH ;
Armstrong, D ;
Albrecht, U ;
Atkins, CM ;
Noebels, JL ;
Eichele, G ;
Sweatt, JD ;
Beaudet, AL .
NEURON, 1998, 21 (04) :799-811
[6]   Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells [J].
Kazantsev, A ;
Preisinger, E ;
Dranovsky, A ;
Goldgaber, D ;
Housman, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11404-11409
[7]   Ataxin-1 nuclear localization and aggregation:: Role in polyglutamine-induced disease in SCA1 transgenic mice [J].
Klement, IA ;
Skinner, PJ ;
Kaytor, MD ;
Yi, H ;
Hersch, SM ;
Clark, HB ;
Zoghbi, HY ;
Orr, HT .
CELL, 1998, 95 (01) :41-53
[8]   Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease [J].
Ona, VO ;
Li, MW ;
Vonsattel, JPG ;
Andrews, LJ ;
Khan, SQ ;
Chung, WM ;
Frey, AS ;
Menon, AS ;
Li, XJ ;
Stieg, PE ;
Yuan, JY ;
Penney, JB ;
Young, AB ;
Cha, JHJ ;
Friedlander, RM .
NATURE, 1999, 399 (6733) :263-267
[9]   Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation [J].
Perez, MK ;
Paulson, HL ;
Pendse, SJ ;
Saionz, SJ ;
Bonini, NM ;
Pittman, RN .
JOURNAL OF CELL BIOLOGY, 1998, 143 (06) :1457-1470
[10]   Caspase-8 is required for cell death induced by expanded polyglutamine repeats [J].
Sánchez, I ;
Xu, CJ ;
Juo, P ;
Kakizaka, A ;
Blenis, J ;
Yuan, JY .
NEURON, 1999, 22 (03) :623-633