Search for Serum Biomarkers Associated with Abdominal Aortic Aneurysm Growth - A Pilot Study

被引：32

作者：

de Ceniga, M. Vega ^{[1
]}

Esteban, M. ^{[2
]}

Quintana, J. M. ^{[3
]}

Barba, A. ^{[1
]}

Estallo, L. ^{[1
]}

de la Fuente, N. ^{[1
]}

Viviens, B. ^{[1
]}

Martin-Ventura, J. L. ^{[4
]}

机构：

[1] Hosp Galdakao Usansolo, Dept Angiol & Vasc Surg, Bizkaia, Spain

[2] Hosp Galdakao Usansolo, Biochem Lab, Bizkaia, Spain

[3] CIBERESP, Hosp Galdakao Usansolo, Res Unit, Galdakao Usansolo, Spain

[4] Univ Autonoma Madrid, Vasc Res Lab, Fdn Jimenez Diaz, Madrid, Spain

来源：

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | 2009年 / 37卷 / 03期

关键词：

Abdominal aortic aneurysm; Serum biomarkers; CRP; Alpha; 1-antitrypsin; Lipoprotein(a); EXPANSION; LEVEL;

D O I：

10.1016/j.ejvs.2008.11.014

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Introduction: Serological biomarkers could reflect asymptomatic infrarenal aortic: aneurysm (AAA) activity and guide patient management. Report: Serum concentrations of C-reactive protein (CRP), alpha 1-antitrypsin and lipoprotein(a) were measured in blood samples from 35 AAA patients and 35 controls and correlated with the aortic diameter and AAA growth in the previous 12 months. We found a positive correlation between CRP and AAA diameter (r = 0.46; p = 0.007) and alpha 1-antitrypsin and AAA growth (r = 0.55; p = 0.004). Conclusions: Alpha 1-antitrypsin may be a promising biomarker of AAA growth. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

引用

页码：297 / 299

页数：3

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