Interaction of mitochondrial voltage-dependent anion channel from rat brain with plasminogen protein leads to partial closure of the channel

被引：14

作者：

Banerjee, J ^{[1
]}

Ghosh, S ^{[1
]}

机构：

[1] Univ Delhi, Dept Biophys, New Delhi 110021, India

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2004年 / 1663卷 / 1-2期

关键词：

rat brain VDAC; plasminogen protein; BLM electrophysiology; gating; regulation;

D O I：

10.1016/j.bbamem.2004.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Voltage-dependent anion channel (VDAC) is reported to be the receptor for plasminogen kringle5. In this paper, the interaction of VDAC from rat brain mitochondria with plasminogen protein has been investigated through bilayer electrophysiological studies. We report for the first time that interaction of plasminogen with VDAC leads to partial closure of the channel on a lipid bilayer. This could be a mechanism of modulation of VDAC gating in a cellular system. (C) 2004 Elsevier B.V. All rights reserved.

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页码：6 / 8

页数：3

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