Immunology - Sugar determines antibody activity

被引：64

作者：

Burton, Dennis R.

Dwek, Raymond A.

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Univ Oxford, Dept Biochem, Glycobiol Inst, Oxford OX1 3QU, England

来源：

SCIENCE | 2006年 / 313卷 / 5787期

关键词：

D O I：

10.1126/science.1131712

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding the functional consequences of the identity and sequence of the sugars attached to antibodies may be useful in designing therapies for a range of disorders.

引用

页码：627 / 628

页数：2

共 12 条

[1] Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease
Bruhns, P
Samuelsson, A
Pollard, JW
Ravetch, JV
[J]. IMMUNITY, 2003, 18 (04) : 573 - 581
[2] The carbohydrate at FcγRIIIa Asn-162 -: an element required for high affinity binding to non-fucosylated IgG glycoforms
Ferrara, C
Stuart, F
Sondermann, P
Brükner, P
Umaña, P
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (08) : 5032 - 5036
[3] Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
Kaneko, Yoshikatsu
Nimmerjahn, Falk
Ravetch, Jeffrey V.
[J]. SCIENCE, 2006, 313 (5787) : 670 - 673
[4] Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity
Krapp, S
Mimura, Y
Jefferis, R
Huber, R
Sondermann, P
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (05) : 979 - 989
[5] GLYCOSYLATION CHANGES OF IGG ASSOCIATED WITH RHEUMATOID-ARTHRITIS CAN ACTIVATE COMPLEMENT VIA THE MANNOSE-BINDING PROTEIN
MALHOTRA, R
WORMALD, MR
RUDD, PM
FISCHER, PB
DWEK, RA
SIM, RB
[J]. NATURE MEDICINE, 1995, 1 (03) : 237 - 243
[6] Role of oligosaccharide residues of IgG1-Fc in FcγRIIb binding
Mimura, Y
Sondermann, P
Ghirlando, R
Lund, J
Young, SP
Goodall, M
Jefferis, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (49) : 45539 - 45547
[7] Divergent immunoglobulin G subclass activity through selective Fc receptor binding
Nimmerjahn, F
Ravetch, JV
[J]. SCIENCE, 2005, 310 (5753) : 1510 - 1512
[8] IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides
Niwa, R
Natsume, A
Uehara, A
Wakitani, M
Iida, S
Uchida, K
Satoh, M
Shitara, K
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 306 (1-2) : 151 - 160
[9] ASSOCIATION OF RHEUMATOID-ARTHRITIS AND PRIMARY OSTEO-ARTHRITIS WITH CHANGES IN THE GLYCOSYLATION PATTERN OF TOTAL SERUM IGG
PAREKH, RB
DWEK, RA
SUTTON, BJ
FERNANDES, DL
LEUNG, A
STANWORTH, D
RADEMACHER, TW
MIZUOCHI, T
TANIGUCHI, T
MATSUTA, K
TAKEUCHI, F
NAGANO, Y
MIYAMOTO, T
KOBATA, A
[J]. NATURE, 1985, 316 (6027) : 452 - 457
[10] Selection, design, and engineering of therapeutic antibodies
Presta, LG
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (04) : 731 - 736

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