IMMUNOHISTOCHEMICAL ANALYSIS FOR CD21, CD35, CALDESMON AND S100 PROTEIN ON DENDRITIC CELLS TYPES IN ORAL LYMPHOMAS

被引：5

作者：

Mesquita, Ricardo Alves ^{[1
]}

de Araujo, Vera Cavalcanti ^{[2
]}

Pinto Paes, Roberto Antonio ^{[3
]}

Nunes, Fabio Daumas ^{[4
]}

Orsini Machado de Sousa, Suzana Cantanhede ^{[4
]}

机构：

[1] Univ Fed Minas Gerais, Fac Odontol, Disciplina Patol Bucal, Sch Dent,Dept Oral Surg Oral Med & Oral Pathol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Sch & Res Ctr Dent Sao Leopoldo Mandic, Dept Oral Pathol, Campinas, SP, Brazil

[3] Hosp Santa Casa Sao Paulo, Dept Pathol Anat, Sao Paulo, Brazil

[4] Univ Sao Paulo, Dept Oral Pathol, Sch Dent, Sao Paulo, Brazil

来源：

JOURNAL OF APPLIED ORAL SCIENCE | 2009年 / 17卷 / 03期

关键词：

CD21; CD35; Follicular dendritic cells; Interdigitating dendritic cells; Immunohistochemistry; Lymphoma; Oral lymphomas; MONOCLONAL-ANTIBODY; LANGERHANS CELLS; S-100; PROTEIN; ANTIGEN; DIFFERENTIATION; DISEASE;

D O I：

10.1590/S1678-77572009000300023

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Objective: Follicular dendritic cells (FDCs) and interdigitating dendritic cells (IDCs) are dendritic cells found in lymphoid follicles, reactive follicles and in lymphomas. The goal of this study was to evaluate the presence and distribution of FDCs and IDCs in oral lymphomas. Material and Methods: Immunohistochemistry reactions were applied to 50 oral lymphomas using the antibodies anti-CD21, anti-CD35 and anti-caldesmon to FDCs, and anti-S100 protein to IDCs. Caldesmon+/FDCs and S100+/IDCs were quantified in Imagelab (R) software. Results: FDCs revealed by CD21 and CD35 were positively stained in two cases of diffuse large B-cell lymphoma, one MALT lymphoma, and in one case of mantle cell lymphoma. FDCs were immunopositive to caldesmon in all cases, as well as IDCs to S100 protein. Burkitt lymphoma presented a lower amount of caldesmon+/FDCs and S100+/IDCs than diffuse large B-cell lymphoma and plasmablastic lymphoma of the oral mucosa type. Conclusions: The microenvironment determined by neoplastic lymphoid cells in oral lymphomas is responsible by the development and expression of dendritic cells types.

引用

页码：248 / 253

页数：6

共 27 条

[1]

Follicular dendritic cells in reactive and neoplastic lymphoid tissues: A reevaluation of staining patterns of CD21, CD23, and CD35 antibodies in paraffin sections after wet heat-induced epitope retrieval [J].