Thrombotic thrombocytopenic purpura during interferon alpha treatment for chronic myelogenous leukemia

被引：19

作者：

Lacotte, L ^{[1
]}

Thierry, A ^{[1
]}

Delwail, V ^{[1
]}

Dreyfus, B ^{[1
]}

Guilhot, F ^{[1
]}

机构：

[1] CHU La Miletrie, Dept Hematol & Clin Oncol, F-86021 Poitiers, France

来源：

ACTA HAEMATOLOGICA | 1999年 / 102卷 / 03期

关键词：

chronic myelogenous leukemia; immunologic effects; interferon alpha; thrombotic thrombocytopenic purpura;

D O I：

10.1159/000040993

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome have recently been observed in patients undergoing interferon alpha (IFN-alpha) therapy. However, the relationship between disease and therapy has not been established, essentially because of concomitant treatment or previous bone marrow transplantation. We present a case of TTP developing during IFN-alpha therapy for chronic myelogenous leukemia. In this case, IFN-alpha seems to be the only etiological agent. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：160 / 162

页数：3

共 18 条

[1] UK MEDICAL-RESEARCH-COUNCIL RANDOMIZED, MULTICENTER TRIAL OF INTERFERON-ALPHA-N1 FOR CHRONIC MYELOID-LEUKEMIA - IMPROVED SURVIVAL IRRESPECTIVE OF CYTOGENETIC RESPONSE [J].

ALLAN, NC ;

RICHARDS, SM ;

SHEPHERD, PCA .

LANCET, 1995, 345 (8962) :1392-1397

[2]

CARLSON K, 1993, BONE MARROW TRANSPL, V11, P205

[3]

CONLON KC, 1990, CANCER, V65, P2237, DOI 10.1002/1097-0142(19900515)65:10<2237::AID-CNCR2820651013>3.0.CO

[4]

2-5

[5] Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome [J].

Furlan, M ;

Robles, R ;

Galbusera, M ;

Remuzzi, G ;

Kyrle, PA ;

Brenner, B ;

Krause, M ;

Scharrer, I ;

Aumann, V ;

Mittler, U ;

Solenthaler, M ;

Lämmle, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (22) :1578-1584

[6] Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia [J].

Guilhot, F ;

Chastang, C ;

Michallet, M ;

Guerci, A ;

Harousseau, JL ;

Maloisel, F ;

Bouabdallah, R ;

Guyotat, D ;

Cheron, N ;

Nicolini, F ;

Abgrall, JF ;

Tanzer, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (04) :223-229

[7] RECOMBINANT INTERFERON-ALPHA AND HEMOLYTIC-UREMIC SYNDROME - CAUSE OR COINCIDENCE [J].

HARVEY, M ;

ROSENFELD, D ;

DAVIES, D ;

HALL, BM .

AMERICAN JOURNAL OF HEMATOLOGY, 1994, 46 (02) :152-153

[8]

NIELD GH, 1994, LANCET, V143, P398

[9]

OHNISHI K, 1995, BLOOD, V86, P906

[10] CLINICAL TOXICITY OF INTERFERONS IN CANCER-PATIENTS - A REVIEW [J].

QUESADA, JR ;

TALPAZ, M ;

RIOS, A ;

KURZROCK, R ;

GUTTERMAN, JU .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (02) :234-243

← 1 2 →