Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption

被引：27

作者：

Dilly, Suzanne J.

Beecham, Matthew P.

Brown, Steven P.

Griffin, John M.

Clark, Andrew J.

Griffin, Craig D.

Marshall, Jacqueline

Napier, Richard M.

Taylor, Paul C.

Marsh, Andrew ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Warwick HRI, Warwick CV35 9EF, England

[3] Univ Warwick, Dept Phys, Coventry CV4 7AL, W Midlands, England

来源：

LANGMUIR | 2006年 / 22卷 / 19期

关键词：

D O I：

10.1021/la060743j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel surfaces derivatized with tertiary amine oxides have been prepared and tested for their ability to resist nonspecific protein adsorption. The oxidation of tertiary amines supported on triazine units was carried out using mCPBA to give a format allowing conjugation of biologically active ligands alongside them. Adsorption to these surfaces was tested and compared to adsorption to a set of commercial and custom oligo-/poly(ethylene glycol) (OEG/PEG) supports by challenging them with a protein display library presented on bacteriophage I. The new class of amine oxide surfaces is found to compare favorably with the performance of the OEG/PEG supports in the prevention of nonspecific binding.

引用

页码：8144 / 8150

页数：7

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