Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime

被引：536

作者：

Steinberg, D ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 11期

关键词：

D O I：

10.1038/nm1102-1211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A historical perspective on atherosclerosis allows us to reflect on the once controversial hypotheses in the field. Plaque formation was once thought to be dependent upon hypercholesterolemia alone, or solely in response to injury. More recently, inflammatory cascades were thought to be at the root of lesion development. A more realistic view may be that atherosclerosis is neither exclusively an inflammatory disease nor solely a lipid disorder: it is both.

引用

页码：1211 / 1217

页数：7

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