Absolute stereostructures of novel cytotoxic metabolites, penostatins A-E, from a Penicillium species separated from an Enteromorpha alga

被引：41

作者：

Iwamoto, C

Minoura, K

Oka, T

Ohta, T

Hagishita, S

Numata, A

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 56911, Japan

[2] Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 553, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 50期

关键词：

D O I：

10.1016/S0040-4020(99)00884-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Penostatins A - E have been isolated tom a strain of Penicillium sp. originally separated tom the marine alga Enteromorpha intestinalis, and their absolute stereostructures and conformations have been established on the basis of spectral analyses and some chemical transformations. All the compounds except for penostatin D exhibited significant cytotoxicity against cultured P388 cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：14353 / 14368

页数：16

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