Biology of colorectal liver metastases: A review

被引：120

作者：

Bird, Nigel C. ^{[1
]}

Mangnall, David ^{[1
]}

Majeed, Ali W. ^{[1
]}

机构：

[1] Royal Hallamshire Hosp, Liver Res Grp, Sheffield S10 2JF, S Yorkshire, England

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2006年 / 94卷 / 01期

关键词：

colorectal cancer; liver metastasis; molecular markers;

D O I：

10.1002/jso.20558

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic growth is a selective, non-random process, which in the case of colorectal cancer, frequently occurs in the liver and is the major cause of cancer related death in these patients. This review summarises attempts to find biological and molecular markers of metastasis and their role in establishment of secondary tumours. Recent evidence suggests that liver metastases are phenotypically different to the primary from which they were derived and thus represent a separate disease entity.

引用

页码：68 / 80

页数：13

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