MicroRNA-34a: Role in Cancer and Cardiovascular Disease

被引：19

作者：

Chen, Xi ^{[1
]}

Zhou, Jian-Ya ^{[1
]}

Zhou, Jian-Ying ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Thorac Dis Diag & Treatment Ctr,Dept Resp Dis, Qingchun Rd 79, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CURRENT DRUG TARGETS | 2014年 / 15卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Cardiovascular diseases; microRNA-34a; molecular target therapy; neoplasms; PAPILLARY THYROID-CARCINOMA; B-CELL LYMPHOMA; TUMOR-SUPPRESSOR; DOWN-REGULATION; MIR-34; FAMILY; MYOCARDIAL-INFARCTION; TARGETED EXPRESSION; INHIBITS MIGRATION; OSTEOSARCOMA CELLS; SYSTEMIC DELIVERY;

D O I：

10.2174/1389450115666140120102935

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.

引用

页码：361 / 373

页数：13

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