The potential role of angiogenic factors in rheumatoid arthritis

被引：73

作者：

Azizi, Gholamreza ^{[1
]}

Boghozian, Roobina ^{[2
]}

Mirshafiey, Abbas ^{[2
]}

机构：

[1] Alborz Univ Med Sci, Imam Hassan Mojtaba Hosp, Karaj, Iran

[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran 14155, Iran

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2014年 / 17卷 / 04期

关键词：

angiogenesis; cytokines; hypoxia; RA; VEGF; ENDOTHELIAL GROWTH-FACTOR; RECOMBINANT HUMAN ENDOSTATIN; FIBROBLAST-LIKE SYNOVIOCYTES; HYPOXIA-INDUCIBLE FACTOR; PSEUDOLARIX ACID-B; SYNOVIAL TISSUE; INTEGRIN ALPHA(V)BETA(3); THERAPEUTIC TARGET; INFLIXIMAB THERAPY; JOINT DESTRUCTION;

D O I：

10.1111/1756-185X.12280

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Angiogenesis is an important phenomenon in the pathogenesis of some diseases, such as numerous types of tumors and autoimmunity, and also a number of soluble and cell-bound factors may stimulate neovascularization in inflammatory reaction processes. Here, by highlighting the significance of angiogenesis reaction in rheumatoid arthritis (RA), we will mainly focus on the role of various growth factors, cytokines, enzymes, cells, hypoxic conditions and transcription factors in the angiogenic process and we will then explain some therapeutic strategies based on blockage of angiogenesis and modification of the vascular pathology in RA.

引用

收藏

页码：369 / 383

页数：15

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