Construction of HIV Rev peptides containing peptide nucleic acid that bind HIV RRE IIB RNA

被引：12

作者：

Kumagai, I

Takahashi, T

Hamasaki, K

Ueno, A

Mihara, H ^{[1
]}

机构：

[1] Tokyo Inst Technol, Fac Biosci & Biotechnol, Dept Bioengn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] Japan Sci & Technol Corp, PRESTO, Form & Funct, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00006-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptides containing peptide nucleic acid (PNA) have been designed and synthesized to construct molecules recognizing a bulge or a loop structure of RNA. Such peptides were here designed from the HIV Rev protein that can bind the stem-loop IIB of the Rev responsive element (RRE) RNA. Variations of PNA modulated the binding affinities of the peptides to RRE IIB RNA. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：377 / 379

页数：3

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