Autophagy-Independent Functions of the Autophagy Machinery

被引：1126

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
,4
]}

Green, Douglas R. ^{[5
]}

机构：

[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[2] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA

[3] Yale Sch Med, Dept Dermatol, New Haven, CT 06510 USA

[4] Univ Paris Descartes Paris V, Paris, France

[5] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

CELL | 2019年 / 177卷 / 07期

基金：

美国国家卫生研究院;

关键词：

C-VPS COMPLEX; CELL-DEATH; BECLIN; CRYSTAL-STRUCTURE; LC3-ASSOCIATED PHAGOCYTOSIS; NONCANONICAL AUTOPHAGY; TUMOR PROGRESSION; DISTINCT ROLES; PROTEIN; UVRAG;

D O I：

10.1016/j.cell.2019.05.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.

引用

页码：1682 / 1699

页数：18

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