Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease

被引：26

作者：

Papassotiropoulos, A ^{[1
]}

Bagli, M ^{[1
]}

Jessen, F ^{[1
]}

Frahnert, C ^{[1
]}

Rao, ML ^{[1
]}

Maier, W ^{[1
]}

Heun, R ^{[1
]}

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

来源：

MOLECULAR PSYCHIATRY | 2000年 / 5卷 / 02期

关键词：

Alzheimer's disease; bleomycin hydrolase; beta-secretase; case-control study; association; polymorphism;

D O I：

10.1038/sj.mp.4000656

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bleomycin hydrolase (BH), a cysteine protease from the papain superfamily, is considered to be a candidate for the beta-secretase, which is presumably involved in the production of beta-amyloid peptide. The G/G genotype of BH was identified as a significant risk factor for the development of Alzheimer's disease (AD) in subjects not carrying the apolipoprotein E epsilon 4 allele (apoE-epsilon 4). However, this finding was recently challenged. We studied this polymorphism in a homogenous sample of German AD patients and controls. The over-representation of the G/G genotype in AD patients could be confirmed, however it was more pronounced in apoE-epsilon 4 carriers. Additional studies should be undertaken to increase the confidence that the BH polymorphism is associated with AD and to explore the relationship between BH and apoE.

引用

页码：213 / 215

页数：3

共 9 条

[1] Human bleomycin hydrolase: Molecular cloning, sequencing, functional expression, and enzymatic characterization [J].