Inhibition of endogenous TGF-β during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair

被引：174

作者：

Scharstuhl, A ^{[1
]}

Glansbeek, HL ^{[1
]}

van Beuningen, HM ^{[1
]}

Vitters, EL ^{[1
]}

van der Kraan, PM ^{[1
]}

van den Berg, WB ^{[1
]}

机构：

[1] Univ Nijmegen, Med Ctr, Dept Rheumatol, Rheumatol Res Lab, NL-6525 GA Nijmegen, Netherlands

来源：

JOURNAL OF IMMUNOLOGY | 2002年 / 169卷 / 01期

关键词：

D O I：

10.4049/jimmunol.169.1.507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteoarthritis has as main characteristics the degradation of articular cartilage and the formation of new bone at the joint edges, so-called osteophytes. In this study enhanced expression of TGF-beta1 and -beta3 was detected in developing osteophytes and articular cartilage during murine experimental osteoarthritis. To determine the role of endogenous TGF-beta on osteophyte formation and articular cartilage, TGF-beta activity was blocked via a scavenging soluble TGF-beta-RII. Our results clearly show that inhibition of endogenous TGF-beta nearly completely prevented osteophyte formation. In contrast, treatment with recombinant soluble TGF-beta-RII markedly enhanced articular cartilage proteoglycan loss and reduced the thickness of articular cartilage. In conclusion, we show for the first time that endogenous TGF-beta is a crucial factor in the process of osteophyte formation and has an important function in protection against cartilage loss.

引用

页码：507 / 514

页数：8

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