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Peroxisome proliferator-activated receptor α/γ dual Agonists for the treatment of type 2 diabetes

被引：130
作者：
Henke, BR [1 ]
机构：
[1] GlaxoSmithKline, Metab & Viral Dis Drug Discovery Res, Res Triangle Pk, NC 27709 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 17期
关键词：
D O I：
10.1021/jm030631e
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：4118 / 4127
页数：10
相关论文
共 63 条
  • [1] Amphipathic 3-phenyl-7-propylbenziscoxazoles;: human PPaR γ, δ and α agonists
    Adams, AD
    Yuen, W
    Hu, Z
    Santini, C
    Jones, AB
    MacNaul, KL
    Berger, JP
    Doebber, TW
    Moller, DE
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (05) : 931 - 935
  • [2] Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity -: Studies with congenic mouse lines
    Akiyama, TE
    Nicol, CJ
    Fievet, C
    Staels, B
    Ward, JM
    Auwerx, J
    Lee, SST
    Gonzalez, FJ
    Peters, JM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) : 39088 - 39093
  • [3] Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
    Aoyama, T
    Peters, JM
    Iritani, N
    Nakajima, T
    Furihata, K
    Hashimoto, T
    Gonzalez, FJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) : 5678 - 5684
  • [4] Insulin resistance in type 2 diabetes: role of fatty acids
    Arner, P
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2002, 18 : S5 - S9
  • [5] PPARγ, the ultimate thrifty gene
    Auwerx, J
    [J]. DIABETOLOGIA, 1999, 42 (09) : 1033 - 1049
  • [6] Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis
    Barbier, O
    Torra, IP
    Duguay, Y
    Blanquart, C
    Fruchart, JC
    Glineur, C
    Staels, B
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (05) : 717 - 726
  • [7] Bocher V, 2002, ANN NY ACAD SCI, V967, P7
  • [8] Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction
    Boden, G
    Shulman, GI
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 : 14 - 23
  • [9] Boden G., 2001, Curr.Opin.Endocrinol.Diabetes, V8, P235
  • [10] Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl)ethoxy]phenoxy}propionic acids:: A new class of dual PPARα/γ agonists
    Brooks, DA
    Etgen, GJ
    Rito, CJ
    Shuker, AJ
    Dominianni, SJ
    Warshawsky, AM
    Ardecky, R
    Paterniti, JR
    Tyhonas, J
    Karanewsky, DS
    Kauffman, RF
    Broderick, CL
    Oldham, BA
    Montrose-Rafizadeh, C
    Winneroski, LL
    Faul, MM
    McCarthy, JR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (13) : 2061 - 2064
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