The resistance of human monocyte-derived macrophages to Chlamydia pneumoniae infection is enhanced by interferon-gamma

被引：13

作者：

Airenne, S ^{[1
]}

Surcel, HM ^{[1
]}

Bloigu, A ^{[1
]}

Laitinen, K ^{[1
]}

Saikku, P ^{[1
]}

Laurila, A ^{[1
]}

机构：

[1] Natl Publ Hlth Inst, FIN-90101 Oulu, Finland

来源：

APMIS | 2000年 / 108卷 / 02期

关键词：

C; pneumoniae; human monocyte-derived macrophages; HL-cells; interferon-gamma; cell culture;

D O I：

10.1034/j.1600-0463.2000.d01-37.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chlamydia pneumoniae is an intracellular bacterium which commonly causes respiratory infections. Chronic infections have been associated with atherosclerosis and the organism has been detected in macrophages in the disease lesions. Growth of chlamydiae in different epithelial cell lines is restricted by interferon-gamma (IFN-gamma), a monocyte activator produced by T cells. We have studied the influence of IFN-gamma on the growth and infectivity of C. pneumoniae in HL-cells and human monocyte-derived macrophages. Low concentrations of the cytokine significantly restricted the growth and productivity of C. pneumoniae in epithelial cells in vitro. In macrophages, however, no effect on the growth of the bacteria in infected cells was found, but high doses clearly restricted the production of infectious progeny. The results suggest that IFN-gamma participates in the resistance to C. pneumoniae. The bacterium is, however, still capable of infecting macrophages that are important in the pathogenesis of atherosclerosis and it may thus participate in the inflammatory process associated with the disease.

引用

页码：139 / 144

页数：6

共 21 条

[1] Chlamydia pneumoniae infection in human monocytes [J].