Siderocalins: siderophore-binding proteins of the innate immune system

被引：48

作者：

Clifton, Matthew C. ^{[1
]}

Corrent, Colin ^{[1
]}

Strong, Roland K. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

BIOMETALS | 2009年 / 22卷 / 04期

关键词：

Siderophores; Siderophore-binding proteins; Bacterial virulence; Bacterial iron acquisition; Innate immunity; GELATINASE-ASSOCIATED LIPOCALIN; RECEPTOR-RELATED PROTEIN; IRON TRANSPORT-SYSTEM; CRYSTAL-STRUCTURE; PATHOGENICITY ISLAND; ESCHERICHIA-COLI; ANTIMICROBIAL ACTIVITY; MEDIATED SUPPRESSION; REPERFUSION INJURY; SHIGELLA-FLEXNERI;

D O I：

10.1007/s10534-009-9207-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have revealed that the mammalian immune system directly interferes with siderophore-mediated iron acquisition through siderophore-binding proteins and that the association of certain siderophores, or siderophore modifications, with virulence is a direct response of pathogens to evade these defenses.

引用

页码：557 / 564

页数：8

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