A universal role for MyD88 in TLR/IL-1R-mediated signaling

被引：382

作者：

Janssens, S ^{[1
]}

Beyaert, R ^{[1
]}

机构：

[1] Ghent Univ VIB, Dept Mol Biomed Res, Unit Mol Signal Transduct Inflammat, B-9000 Ghent, Belgium

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(02)02145-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.

引用

页码：474 / 482

页数：9

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