A surprising function for SRP RNA?

被引:8
作者
Bernstein, HD [1 ]
机构
[1] NIDDKD, Genet & Biochem Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/73265
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
The crystal structure of the universal ribonucleoprotein core of the signal recognition particle suggests that the RNA moiety has been evolutionarily conserved because it plays an important role in signal sequence recognition.
引用
收藏
页码:179 / 181
页数:3
相关论文
共 31 条
[1]
ANDREWS DW, 1992, J BIOL CHEM, V267, P7761
[2]
BATEY RT, 2000, IN PRESS SCIENCE
[3]
THE 4.5 S RNA GENE OF ESCHERICHIA-COLI IS ESSENTIAL FOR CELL-GROWTH [J].
BROWN, S ;
FOURNIER, MJ .
JOURNAL OF MOLECULAR BIOLOGY, 1984, 178 (03) :533-550
[4]
REQUIREMENT OF GTP HYDROLYSIS FOR DISSOCIATION OF THE SIGNAL RECOGNITION PARTICLE FROM ITS RECEPTOR [J].
CONNOLLY, T ;
RAPIEJKO, PJ ;
GILMORE, R .
SCIENCE, 1991, 252 (5009) :1171-1173
[5]
Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle [J].
deGier, JWL ;
Mansournia, P ;
Valent, QA ;
Phillips, GJ ;
Luirink, J ;
vonHeijne, G .
FEBS LETTERS, 1996, 399 (03) :307-309
[6]
Structure of the conserved GTPase domain of the signal recognition particle [J].
Freymann, DM ;
Keenan, RJ ;
Stroud, RM ;
Walter, P .
NATURE, 1997, 385 (6614) :361-364
[7]
Global transposon mutagenesis and a minimal mycoplasma genome [J].
Hutchison, CA ;
Peterson, SN ;
Gill, SR ;
Cline, RT ;
White, O ;
Fraser, CM ;
Smith, HO ;
Venter, JC .
SCIENCE, 1999, 286 (5447) :2165-2169
[8]
ROLE OF POSITIVE CHARGE ON THE AMINO-TERMINAL REGION OF THE SIGNAL PEPTIDE IN PROTEIN SECRETION ACROSS THE MEMBRANE [J].
INOUYE, S ;
SOBERON, X ;
FRANCESCHINI, T ;
NAKAMURA, K ;
ITAKURA, K ;
INOUYE, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3438-3441
[9]
Crystal structure of the signal sequence binding subunit of the signal recognition particle [J].
Keenan, RJ ;
Freymann, DM ;
Walter, P ;
Stroud, RM .
CELL, 1998, 94 (02) :181-191
[10]
In vitro studies with purified components reveal signal recognition particle (SRP) and SecA SecB as constituents of two independent protein-targeting pathways of Escherichia coli [J].
Koch, HG ;
Hengelage, T ;
Neumann-Haefelin, C ;
MacFarlane, J ;
Hoffschulte, HK ;
Schimz, KL ;
Mechler, B ;
Müller, M .
MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (07) :2163-2173