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Slight association between type 1 diabetes and "ff " VDR FokI genotype in patients from the Italian Lazio Region.: Lack of association with diabetes complications

被引：38
作者：
Capoluongo, E.
Pitocco, D.
Concolino, P.
Santonocito, C.
Di Stasio, E.
d'Onofrio, G.
Manto, A.
Giardina, B.
Ghirlanda, G.
Ameglio, F.
Zuppi, Cecilia
机构：
[1] Inst Biochem & Clin Biochem, Mol Biol Lab, I-00168 Rome, Italy
[2] Inst Internal Med, I-00168 Rome, Italy
[3] Catholic Univ, Trasfus Blood Unit, I-00168 Rome, Italy
[4] IRCCS, Clin Pathol Lab, Foggia, Italy
来源：
CLINICAL BIOCHEMISTRY | 2006年 / 39卷 / 09期
关键词：
VDR; FokI; BsmI; T1DM; complications;
D O I：
10.1016/j.clinbiochem.2006.05.006
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Vitamin D receptor (VDR) mediates the effects of vitamin D. Our paper evaluates the FokI and BsmI VDR genotypes in 246 Caucasian (Italian from Lazio Region) T1DM patients compared with 246 Caucasian healthy controls, sharing age and gender and regional provenience with the patients. In addition, T1DM patients without complications were compared with those carrying three complications. Methods: Genotyping has been obtained by RFLP-PCR technique. Results: A slight significant association of T1DM with FokI homozygous "f" genotype was observed. No association. was observed with the presence of multiple complications by a multivariate analysis. Conclusion: T1DM patients showed slightly increased prevalence of "ff" VDR genotype. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved.
引用
收藏
页码：888 / 892
页数：5
相关论文
共 25 条
[1]  
ALDINGTON SJ, 1995, DIABETOLOGIA, V38, P437, DOI 10.1007/BF00410281
[2]  
Amer Diabet Assoc, 2005, DIABETES CARE, V28, pS37
[3]   Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects:: A case-parent study [J].
Angel, B ;
Santos, JL ;
Carrasco, E ;
Albala, C ;
Pérez-Bravo, F .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2004, 19 (12) :1085-1087
[4]   Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families [J].
Cox, NJ ;
Wapelhorst, B ;
Morrison, VA ;
Johnson, L ;
Pinchuk, L ;
Spielman, RS ;
Todd, JA ;
Concannon, P .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) :820-830
[5]   Vitamin D supplement in early childhood and risk for Type I (insulin- dependent) diabetes mellitus [J].
Dahlquist G. .
Diabetologia, 1999, 42 (1) :51-54
[6]   SPSS and SAS programming for the testing of mediation models [J].
Dudley, WN ;
Benuzillo, JG ;
Carrico, MS .
NURSING RESEARCH, 2004, 53 (01) :59-62
[7]   Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes [J].
Eerligh, P ;
Koeleman, BPC ;
Dudbridge, F ;
Bruining, GJ ;
Roep, BO ;
Giphart, MJ .
GENES AND IMMUNITY, 2004, 5 (01) :36-40
[8]   VDR gene polymorphisms are overrepresented in German patients with type 1 diabetes compared to healthy controls without effect on biochemical parameters of bone metabolism [J].
Fassbender, WJ ;
Goertz, B ;
Weismüller, K ;
Steinhauer, B ;
Stracke, H ;
Auch, D ;
Linn, T ;
Bretzel, RG .
HORMONE AND METABOLIC RESEARCH, 2002, 34 (06) :330-337
[9]   A 1α,25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice [J].
Gregori, S ;
Giarratana, N ;
Smiroldo, S ;
Uskokovic, M ;
Adorini, L .
DIABETES, 2002, 51 (05) :1367-1374
[10]   The vitamin D receptor gene start codon polymorphism:: A functional analysis of FokI variants [J].
Gross, C ;
Krishnan, AV ;
Malloy, PJ ;
Eccleshall, TR ;
Zhao, XY ;
Feldman, D .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (11) :1691-1699
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