Characterisation of the core part of the lipopolysaccharide O-antigen of Francisella novicida (U112)

被引：16

作者：

Vinogradov, E ^{[1
]}

Perry, MB ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada

来源：

CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 09期

关键词：

Francisella; Francisella novicida; LPS; core structure;

D O I：

10.1016/j.carres.2004.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fransicella novicida (U112), a close relative of the highly virulent bacterium F tularensis, is known to produce a lipopolysaccharide that is significantly different in biological properties from the LPS of F tularensis. Here we present the results of the structural analysis of the F novicida LPS core part, which is found to be similar to that of F tularensis, differing only by one additional alpha-Glc residue: [GRAPHICS] where R is an beta-chain, linked via a beta-bacillosamine (2,4-diamino-2,4,6-trideoxyglucose) residue. The lipid part of F novicida LPS contains no phosphate substituent and apparently has a free reducing end, a feature also noted in F tularensis LPS. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1643 / 1648

页数：6

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